Exploratory/Developmental Bioengineering Research Grants (EBRG) – R21
The EBRGs support early bioengineering concepts in basic biomedical, pre-clinical, or clinical research, clinical care delivery, or accessibility. EBRG applications may contain minimal or no preliminary data, and may propose hypothesis-driven, discovery-driven or design-directed research to demonstrate feasibility and potential utility of new capabilities or improvements in quality, speed, efficacy, operability, costs, and/or accessibility.
Most recent issuance: PAR-25-321 and PAR-25-346.
Bioengineering Research Grants (BRG) – R01
The BRGs support multi-disciplinary biomedical research performed in in a single laboratory or by multiple organizations. BRG applications may propose hypothesis-driven, discovery-driven, developmental, or design-directed research. BRGs are appropriate for small teams applying an integrative approach to understanding and solving problems in biological, clinical or translational science.
Most recent issuance: PAR-22-242
Academic-Industrial Partnerships for Translation of Technologies for Diagnosis and Treatment – R01
Academic-Industrial Partnership (AIP) awards support translation of scientific discoveries and engineering developments into methods or tools that address problems in basic research to understand disease or to assess risk (in applied research). These discoveries aim to detect, prevent, diagnose, treat, and/or manage disease. The rationale is to deliver new capabilities to meet evolving requirements for technologies and methods relevant to the advance of research and delivery of care in pre-clinical, clinical and non-clinical settings. They are awarded to domestic and foreign organizations, for conditions and diseases within the missions of participating institutes. This Notice of Funding Opportunities (NOFO) specifies a partnership structure that is expected to help bridge gaps in knowledge and experience by engaging the strengths of academic, industrial, and other investigators. This NOFO defines innovation as the likelihood to deliver a new capability to end users.
Most recent issuance: PAR-25-338
Bioengineering Partnerships with Industry (BPI) – U01
BPI awards support projects that create research partnerships between academic and industrial investigators to address important biomedical problems. They do this by accelerating the development and adoption of promising bioengineering tools and technologies. BPI applications should involve multidisciplinary teams that apply an integrative, quantitative bioengineering approach to developing technologies. The goal of the program is to support technological innovations that deliver new capabilities which can realize meaningful solutions within 5–10 years.
Most recent issuance: PAR-24-325
Innovative Molecular Analysis Technologies (IMAT) Initiatives – R61 & R33
The IMAT program was established to support the early-stage development, technical maturation, and dissemination of novel and potentially transformative next-generation technologies through an approach of balanced but targeted innovation.
ITCR - NCI’s Program for Informatics Technology Development U01, U24
The central mission of the Informatics Technology for Cancer Research (ITCR) program is to promote research-driven informatics technology across the development lifecycle to address priority needs in cancer research.